Research across 14 topics
Broccoli Sprouts and Sulforaphane:
Research on Cells and Health
68 papers across 14 topics.
Explore findings from human, animal, and cell studies with links to the original sources.
Research review · Wellbeing200 Co., Ltd.
Cognitive Health
12-week trials of processing speed and working memory in older adults
Two 12-week trials in healthy older adults found improved processing speed in glucoraphanin groups. The 2021 trial also observed improvement in working memory.
Sleep and Mood
A controlled mood trial and a pilot sleep study
In a 12-week trial of 144 older adults, negative mood scores improved versus placebo. An 18-person pilot sleep study found no significant between-group difference.
Cancer-Related Mechanisms
Early studies of cancer-related cellular and tissue markers
Mice given intraperitoneal sulforaphane injections had a lower tumor mitotic index. Early human trials assessed PSA, tissue markers, survival, and the feasibility of continued intake.
Antioxidant and Cellular Defense
Antioxidant defense and urinary excretion of a benzene metabolite
Antioxidant defense gene activity increased after sprout intake. A separate trial found increased urinary excretion of a benzene metabolite.
Liver Health
Lower ALT observed in a 24-week controlled trial
In a trial of 70 middle-aged adults with liver enzyme values near the upper limit of normal, ALT was lower in the glucoraphanin group than in the placebo group after adjustment for baseline values.
Blood Glucose and Metabolism
A small fasting-glucose change in adults with prediabetes
In a 12-week trial, fasting glucose was 0.2 mmol/L lower on average than with placebo. This fell short of the prespecified 0.3 mmol/L reduction target. Researchers also explored how metabolic and gut microbial characteristics related to response.
Lipid Metabolism and Inflammation
Controlled human trials assessing LDL and triglycerides
A pooled analysis of two 12-week trials found a greater LDL reduction with high-glucoraphanin broccoli than with standard broccoli. A separate 4-week trial in people with diabetes observed lower triglycerides and higher HDL.
Gut Health and Microbiota
Changes in constipation scores and gut microbial composition
Constipation discomfort scores were lower after four weeks in the broccoli sprout group. A separate controlled diet trial observed different gut microbial composition with a broccoli and raw daikon radish diet.
Cardiovascular Health and Lipids
LDL changes in two 12-week broccoli diet trials
LDL cholesterol decreased in two 12-week diet trials of high-glucoraphanin broccoli.
Skin Health
An exploratory trial of skin defense-gene activity
In an exploratory trial of 18 healthy adults, skin NQO1 expression rose from baseline in the glucoraphanin group. No significant change in redness after UV exposure was established.
Autism Spectrum
Human studies of hyperactivity and social responsiveness
Some human trials and meta-analyses reported improvements in hyperactivity and social responsiveness measures. Results varied by participant age, rater, and outcome.
Pancreatic Health
Pancreatic-cell mechanisms and related human studies
Mice given sulforaphane had less pancreatic inflammation and tissue damage. Related human trials examined glucose and insulin secretion in prediabetes and feasibility of continued intake in pancreatic cancer.
Pain Sensitivity
Small human trials of knee and muscle pain
Pilot studies observed less pain with knee osteoarthritis and post-exercise muscle tenderness. A 15-person powder versus placebo crossover trial found no significant difference in muscle soreness or strength recovery.
Stomach Health
H. pylori colonization and gastric inflammation markers
The studies include an eight-week sprout intake trial in infected adults and a comparison of sprout powder with standard eradication therapy.
MANMEOKSUL
Redefining health
at the cellular level.
Prepare sulforaphane with MANMEOKSUL.
100% broccoli sprout powder for the sulforaphane routine.