Cardiovascular health and lipids
Cardiovascular & Lipids
Lower LDL cholesterol, one aspect of cardiovascular health management
LDL is an important marker in cardiovascular health management. LDL fell in two 12 week trials of glucoraphanin rich broccoli.
- 130 participants
- Combined total for the two LDL trials
- 12 weeks
- Duration of each trial
- 400 g/week
- Amount of broccoli consumed
LDL Reduction · Trial 1
Reduction from baseline · %
37 participants · longer bars indicate a larger reduction
Broccoli 400 g/week · 12 weeks
Read Armah · 2015 →View values and units
| Group | Value |
|---|---|
| Standard broccoli | 1.8 |
| High-GLR broccoli | 7.1 |
LDL Reduction · Trial 2
Reduction from baseline · %
93 participants · pooled between-group p = 0.031 in the original paper
Broccoli 400 g/week · 12 weeks
Read Armah · 2015 →View values and units
| Group | Value |
|---|---|
| Standard broccoli | 2.5 |
| High-GLR broccoli | 5.1 |
Cardiovascular health and lipids · research results at a glance
5 studies
Key human studies · LDL cholesterol and blood pressure
| Study and participants | Intake and observation | Findings and context |
|---|---|---|
| Connolly · 2024 18 adults with mildly elevated blood pressure |
Approximately 300 g/day of cruciferous vegetables Two weeks per diet · compared with root and squash vegetables | 24 hour systolic blood pressure difference: −2.5 mmHgFinding: The 24 hour mean systolic blood pressure was lower than with the comparison diet. The between group difference was −2.5 mmHg (p = 0.002). Context: Compared the effects of a diet containing various cruciferous vegetables for two weeks. |
| Armah · 2015 Two independent randomized trials |
Broccoli 400g/week · 12 weeks GLR-rich versus standard variety | LDL decreased 7.1% and 5.1% in two trialsFinding: LDL fell 7.1% and 5.1% in the high GLR groups and 1.8% and 2.5% in the standard groups. The pooled between group comparison had p = 0.031. Context: Within group changes in two 12 week dietary trials and a pooled between group difference of p = 0.031; the measure was LDL. |
Related human trials · vascular function and metabolic markers
| Study and participants | Intake and observation | Findings and context |
|---|---|---|
| Medina · 2015 24 healthy participants |
Single 30 g or 60 g sprout intake 24-hour metabolite measurement | Finding: Some urinary metabolites related to inflammation and vascular responses decreased. Context: Observed for 24 hours after a single intake. Isoprostanes did not change. |
| Mirmiran · 2014 Diabetes with H. pylori infection |
Powder 6 g/day for 28 days Eradication therapy, powder alone, or both | Finding: Systolic and diastolic blood pressure fell in the group receiving both sprout powder and standard eradication therapy. Context: Result from combined treatment including subgroup analysis after eradication. |
| Christiansen · 2010 41 adults with hypertension recruited |
Dried sprouts 10 g/day · four weeks Usual diet control | Finding: Improvements in endothelial function (FMD) and blood pressure did not differ significantly. Context: A four week dried sprout trial in adults with hypertension. |
Sources
- Connolly et al. BMC Med. 2024;22:353.DOI 10.1186/s12916-024-03577-8
- Armah, et al. Mol Nutr Food Res. 2015;59:918-926.DOI 10.1002/mnfr.201400863
- Medina, et al. Food Chem. 2015;173.DOI 10.1016/j.foodchem.2014.10.152
- Mirmiran, et al. J Diabetes Metab Disord. 2014;13:64.DOI 10.1186/2251-6581-13-64
- Christiansen, et al. PLoS One. 2010;5:e12461.DOI 10.1371/journal.pone.0012461