Christiansen · 2010 · PloS one
Controlled trial of vascular function in adults with hypertension
Would the vascular response proposed in animals also appear in adults with hypertension consuming sprouts?
Human · randomized controlled trial
Key findings
Vascular function and blood pressure
A four-week trial of 40 adults with hypertension found no significant improvement versus control in endothelial function (FMD), blood pressure, or blood tests.
Flow-Mediated Dilation · 4-Week Change
FMD · %
Between-group difference was not significant
Two participants contributed substantially to the intake-group mean change
Read the original paper and sources ↓View values and units
| Group | Value |
|---|---|
| Intake · baseline | 4.0 |
| Intake · week 4 | 5.8 |
| Control · baseline | 4.0 |
| Control · week 4 | 3.9 |
Study design
Forty-one adults with hypertension were recruited to consume 10 g/day of dried sprouts for four weeks or continue their usual diet. Assessors blinded to assignment measured blood pressure and flow-mediated dilation (FMD).
- Participants
- 41 adults with hypertension recruited
Small randomized controlled trial - Intake and observation
- Dried sprouts 10 g/day · four weeks
Usual diet control - Measures
- Flow-mediated dilation (FMD) · blood pressure
Study context
The group consuming dried sprouts was compared with a group maintaining its usual diet. Two participants with large changes accounted for most of the mean increase in FMD in the sprout group.
Original paper and sources
Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension.
- Journal
- PloS one · 2010 · 5(8): e12461
- First published
- 2010-08-27