Medina · 2015 · Food chemistry
Urinary inflammation and vascular markers after sprout intake
Do urinary metabolites related to inflammatory and vascular responses change after one serving of sprouts?
Human · single-dose biomarker study
Key findings
Increase in compound metabolites
Urinary concentrations of sulforaphane metabolites and vitamin C rose.
Certain inflammation- and vascular-related markers
tetranor-PGEM, 11β-PGF2α, and 11-dehydro-TXB2 decreased.
Oxidative damage marker was not significant
Isoprostanes, markers related to oxidative stress, were not significantly affected.
Study design
Twenty-four healthy adults consumed 30 g or 60 g of fresh sprouts. Urine was then analyzed for sulforaphane metabolites, vitamin C, and 13 eicosanoids.
- Participants
- 24 healthy participants
- Intake and observation
- Single 30 g or 60 g sprout intake
24-hour metabolite measurement - Measures
- Prostanoids · isoprostanes
Study context
Urinary metabolite changes were examined over 24 hours after a single sprout intake.
Original paper and sources
The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans.
- Journal
- Food chemistry · 2015 · 173: 1187-1194
- First published
- 2014-11-07