Skin and inner beauty
Skin & Inner Beauty
Cellular defense gene response observed in skin after intake
In an exploratory trial of 18 healthy adults, skin NQO1 gene expression rose from baseline in the glucoraphanin group. Redness after UV exposure did not change significantly.
- 18 participants
- Three ingredient comparison
- 8 days
- Duration of intake
- 6 participants
- GLR only group
Cell Defense Gene · NQO1
GLR group · relative expression, baseline = 1
Skin gene response
GLR 450 mg/day · 6 participants in this group
Read Chien · 2025 →View values and units
| Group | Value |
|---|---|
| Baseline | 1.0 |
| Day 8 | 3.1 |
Skin and inner beauty · research results at a glance
5 studies
Exploratory trial of skin gene response after intake
| Study and participants | Intake and observation | Findings and context |
|---|---|---|
| Chien · 2025 18 healthy participants / six per group |
GLR 450 mg/day or curcumin 1 g/day or both oral intake for eight days | Skin NQO1 gene expression was 3.1 times baseline in the GLR groupFinding: Skin expression of the cellular defense gene NQO1 was 3.1 times baseline in the GLR group. Context: An oral trial of skin gene responses. Changes in redness after UV exposure and blood cell markers were not significant. |
Kale extract · uncontrolled before and after observation
| Study and participants | Intake and observation | Findings and context |
|---|---|---|
| Manesh · 2026 49 women aged 35–55 years completed the study |
Kale extract 150 mg/day GLR ≥17% · 56 days | Skin water loss: 17.8 → 16.3 g/h/m²Finding: Skin water loss fell from 17.8 to 16.3 g/h/m² and wrinkle depth decreased after 56 days of intake. Context: An uncontrolled trial of kale extract in women. |
Related research · skin exposure and topical use
| Study and participants | Intake and observation | Findings and context |
|---|---|---|
| Tahata · 2018 17 participants, including people with a history of melanoma |
SFN 50, 100, or 200 μmol/day 28 days · no placebo group | Finding: Blood and skin exposure to sulforaphane increased with oral dose; all 17 participants completed 28 days. Context: An early trial without placebo evaluating exposure and tolerability. |
| Knatko · 2015 24 healthy participants |
Three applications of SFN extract Compared with GLR extract | Finding: Redness after simulated sunlight exposure decreased at sites treated with SFN extract. Context: A comparison across skin sites testing a topical application. |
| Talalay · 2007 Six healthy participants |
Sprout extract applied to skin Erythema measured after UV exposure | Finding: Redness after UV exposure was 37.7% lower on average at skin sites treated with extract. Context: An extract was applied directly to the skin of six healthy participants. |
Sources
- Chien, et al. Metabolites. 2025;15:360.DOI 10.3390/metabo15060360
- Jahangiri Manesh, et al. Cosmetics. 2026;13:47.DOI 10.3390/cosmetics13010047
- Tahata, et al. Cancer Prev Res. 2018;11.DOI 10.1158/1940-6207.CAPR-17-0268
- Knatko et al. Cancer Prev Res. 2015;8:475-486.DOI 10.1158/1940-6207.CAPR-14-0362
- Talalay et al. PNAS. 2007;104:17500-17505.DOI 10.1073/pnas.0708710104