Tahata · 2018 · Cancer prevention research (Philadelphia, Pa.)
Skin delivery and tolerability of oral sulforaphane
How much sulforaphane appears in blood and skin after sprout-extract intake?
Human · pilot distribution study at three doses
Key findings
Median skin concentrations by dose
After 28 days, median skin SFN concentrations were 0.0, 3.1, and 34.1 ng/g in the 50, 100, and 200 μmol groups, respectively.
Blood exposure also rose by dose.
Median increases in blood concentrations by dose group were 120, 206, and 655 ng/mL. Blood and skin were measured in different units.
17 completed in total
All participants completed 28 days without dose-limiting toxicity. These results describe short-term tolerability and distribution in the body.
Skin Sulforaphane Concentration at Day 28
Median skin SFN · ng/g
Skin sulforaphane concentration by dose
17 participants · oral extract · 28 days
Read the original paper and sources ↓View values and units
| Group | Value |
|---|---|
| 50 μmol/day | 0.0 |
| 100 μmol/day | 3.1 |
| 200 μmol/day | 34.1 |
Study design
Seventeen people with a history of melanoma and atypical nevi consumed one of three SFN doses, 50, 100, or 200 μmol/day, for 28 days. Blood and skin exposure, tolerability, and tissue measures were assessed without a placebo group.
- Participants
- 17 participants, including people with a history of melanoma
- Intake and observation
- SFN 50, 100, or 200 μmol/day
28 days · no placebo group - Measures
- SFN in skin and blood · tolerability
Study context
A 28-day study of 17 participants assessed skin and blood distribution and short-term tolerability at three doses.
Original paper and sources
Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.
- Journal
- Cancer prevention research (Philadelphia, Pa.) · 2018 · 11(7): 429-438
- First published
- 2018-04-24