Knatko · 2015 · Cancer prevention research (Philadelphia, Pa.)
NRF2 activity and skin response to simulated sunlight
How do NRF2 activation and topical sulforaphane affect skin exposed to simulated sunlight?
Animal and human · topical skin mechanism experiments
Key findings
Erythema response in human skin
The site treated with SFN extract showed a lower erythema response after simulated sunlight.
A different intervention in animals
Animal findings on tumors and inflammation included genetic manipulation and a separate compound, TBE-31.
NRF2 and skin defense genes
NRF2 activation and the response of skin defense genes were examined.
Study design
Animals were tested with genetic NRF2 activation and a separate activating compound. In 24 humans, SFN-containing extract was applied to skin sites three times and compared with GLR extract.
- Participants
- 24 healthy participants
Comparison of skin sites - Intake and observation
- Three applications of SFN extract
Compared with GLR extract - Measures
- Erythema after simulated sunlight · NRF2
Study context
The NRF2 pathway was studied using topical application in humans and genetic manipulation and a separate active compound in animals.
Original paper and sources
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.
- Journal
- Cancer prevention research (Philadelphia, Pa.) · 2015 · 8(6): 475-486
- First published
- 2015-03-24