Yanaka · 2009 · Cancer prevention research (Philadelphia, Pa.)
H. pylori infection and sprout intake
How does broccoli sprout intake affect H. pylori colonization and gastric inflammation measures?
Human and animal · comparative trial of infection measures
Key findings
Reduction in infection and inflammation measures
Test measures reflecting bacterial colonization and gastric inflammation fell in the broccoli sprout group.
Return toward baseline after discontinuation
Two months after intake stopped, related values returned to baseline.
Animal data for the NRF2 mechanism
Mice lacking NRF2 were used as a comparison to examine the defense pathway's role. This was a mechanistic experiment distinct from the human trial.
Study design
Forty-eight infected adults were assigned to 70 g/day of broccoli sprouts or alfalfa control for eight weeks. Urea breath tests, stool antigen, and serum pepsinogen were measured, alongside a separate mouse experiment.
- Participants
- Adults with H. pylori infection
48 participants · sprout comparison trial - Intake and observation
- Broccoli sprouts 70 g/day
Eight weeks · alfalfa control - Measures
- Urea breath test · stool antigen · pepsinogen
Study context
A trial measuring H. pylori colonization and gastric inflammation. Related values returned to baseline two months after intake stopped.
Original paper and sources
Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.
- Journal
- Cancer prevention research (Philadelphia, Pa.) · 2009 · 2(4): 353-360
- First published
- 2009-04-01