Nouchi · 2022 · Frontiers in aging neuroscience
Glucoraphanin, processing speed, and mood
Would 12 weeks of glucoraphanin intake change cognitive test results and mood in older adults?
Human · randomized double-blind controlled trial
Key findings
Difference in a processing-speed test
The mean change in symbol search (SS) score was +1.29 points in the placebo group and +1.99 in the intake group. The adjusted between-group p-value was 0.03.
Negative mood changes were also compared
Change in total mood disturbance (TMD) score was +1.60 points in the placebo group and −0.11 in the intake group. Lower scores indicate less negative mood; the adjusted p-value was 0.03.
Other test results are reported separately
There were no clear between-group differences in other cognitive tests or in oxidative stress, inflammation, and neuroplasticity markers. Urinary sulforaphane metabolites were higher in the intake group.
Processing Speed · Mean Change
Mean change in SS test score · points
Higher scores indicate better processing speed · adjusted p = 0.03
144 participants · 12 weeks · GLR 30 mg/day
Read the original paper and sources ↓View values and units
| Group | Value | Standard deviation |
|---|---|---|
| Placebo | 1.29 | 4.76 |
| GLR group | 1.99 | 3.83 |
Negative Mood · Mean Change
Mean change in TMD score · points
Lower scores indicate less negative mood · adjusted p = 0.03
144 participants · 12 weeks · measured separately from sleep
Read the original paper and sources ↓View values and units
| Group | Value | Standard deviation |
|---|---|---|
| Placebo | 1.60 | 9.40 |
| GLR group | −0.11 | 6.95 |
Study design
A total of 144 healthy adults aged 60–80 were randomly assigned to the intake or placebo group. They took 30mg of glucoraphanin daily; cognitive tests, mood questionnaires, and biomarkers were compared at baseline and after 12 weeks.
- Participants
- Japan · 144 adults aged 60–80
compared with ingredient-free capsules - Intake and observation
- Glucoraphanin 30mg/day
12 weeks · two-group comparison - Measures
- Processing speed SS · mood TMD
Study context
A 12-week trial examined processing speed and mood in healthy older adults. The supplement dose refers to glucoraphanin, a sulforaphane precursor.
Original paper and sources
Effects of sulforaphane intake on processing speed and negative moods in healthy older adults: Evidence from a randomized controlled trial.
- Journal
- Frontiers in aging neuroscience · 2022 · 14: 929628
- First published
- 2022-07-29