Guo · 2025 · Brain & development
Pooled controlled-trial results focused on ABC and SRS
Which behavior-rating signals remain when several controlled trials are pooled?
Literature · systematic review and meta-analysis
Key findings
Signals in some behavioral domains
Signals of improvement were reported in irritability and hyperactivity domains.
Analyses by scale and observation period
ABC and SRS subdomains were analyzed separately by observation period.
Pooled analysis of earlier trials
A pooled analysis of earlier trials that also includes registry results.
Detailed results
Behavioral and social responsiveness outcomes from several controlled trials were pooled.
Controlled sulforaphane trials were pooled, focusing on ABC and SRS. ABC subdomains such as irritability, hyperactivity, and social withdrawal were also analyzed.
Significant improvements were reported in irritability and hyperactivity.
Why the conclusions differ somewhat from other meta-analyses
Pooled results can differ by selected scales, subdomains, observation times, and pooling methods. In Wang's analysis, the hyperactivity difference was significant, while irritability was not.
Characteristics of the included original trials
Included trials varied in formulation, age, concomitant medication, and rater. The Guo, Wang, and Long meta-analyses include some of the same original studies.
Study design
Controlled trials were identified in literature databases and their ABC and SRS results pooled. The analysis included results from a ClinicalTrials.gov-registered trial as well as published papers.
- Participants
- Six controlled trials · 333 participants total
Five published papers + one set of registry results - Intake and observation
- Literature search through July 2024
Combined ABC and SRS outcomes - Measures
- ABC subscales, SRS, and risk of bias by study
Study context
This pooled analysis uses earlier controlled trials. The Guo, Wang, and Long meta-analyses include some of the same original studies.
Original paper and sources
Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis.
- Journal
- Brain & development · 2025 · 47(2): 104321
- First published
- 2025-02-14