Yanaka · 2024 · Functional Foods in Health and Disease
Sprouts and calprotectin in ulcerative colitis
Does adding sprouts to mesalazine treatment change inflammation measures in patients with mild ulcerative colitis?
Human · sprout comparison during existing treatment
Key findings
Reduction in inflammation markers
Fecal calprotectin fell in the broccoli sprout group. It is a marker of colonic mucosal inflammation.
Changes in certain taxa
The proportion of Clostridium clusters IV and XIVa, associated with butyrate production, increased.
No change in clinical disease activity
Clinical disease activity did not change in either sprout group.
Study design
Twenty-eight participants were assigned equally to broccoli or alfalfa sprouts. They consumed 20 g/day for eight weeks; 12 and 11 participants, respectively, completed the study. Existing mesalazine treatment continued.
- Participants
- Mild ulcerative colitis
28 assigned / 23 completed - Intake and observation
- Sprouts 20 g/day · eight weeks
Alfalfa control · mesalazine treatment - Measures
- Fecal calprotectin · clinical disease activity
Study context
Sprouts were added while existing mesalazine treatment continued. A fecal inflammation marker fell while clinical disease activity remained stable.
Original paper and sources
Dietary intake of sulforaphane-rich broccoli sprouts decreases fecal calprotectin levels in patients with ulcerative colitis
- Journal
- Functional Foods in Health and Disease · 2024 · 14(10): 688-703
- First published
- 2024-10-10