Yan · 2023 · Frontiers in pharmacology
Sulforaphane pathways studied in liver disease
Which sulforaphane pathways have been studied in relation to liver fat accumulation, inflammation, and fibrosis?
Literature review · liver disease mechanisms
Key findings
Pathways related to liver injury
The review describes pathways involved in fat accumulation, insulin sensitivity, oxidative damage, and inflammation.
Preclinical evidence
Many of these mechanisms were observed in cells and animals.
Challenges for practical use
The authors discuss compound stability, solubility, and individual bioavailability differences as practical challenges.
Study design
The authors reviewed previous cell, animal, and some human studies of liver disease. They summarized pathways related to oxidative stress, inflammation, metabolic regulation, and cell growth.
- Participants
- Review of liver disease mechanisms
Synthesis of existing literature - Intake and observation
- Oxidative stress and inflammation
pathways of liver injury and fibrosis - Measures
- Liver injury · oxidative stress · signaling pathways
Study context
A literature review focused on cell and animal studies of pathways related to liver injury.
Original paper and sources
Therapeutic potential of sulforaphane in liver diseases: a review.
- Journal
- Frontiers in pharmacology · 2023 · 14: 1256029
- First published
- 2023-08-29