Traka · 2019 · The American journal of clinical nutrition
Broccoli soup and prostate tissue genes
Would a year of broccoli soups with different glucoraphanin contents change gene expression in prostate tissue?
Human · ESCAPE randomized controlled trial
Key findings
Differences in gene expression
Changes in inflammation- and epithelial–mesenchymal transition-related genes observed in the standard soup group appeared attenuated in the GLR-rich soup group.
Dietary comparison by GLR content
The same amount of soup was prepared with different GLR contents. This was a food intervention using broccoli soup.
Tissue response as the primary assessment
RNA analysis of prostate tissue assessed gene responses related to inflammation and epithelial–mesenchymal transition.
Study design
Sixty-one patients with prostate cancer under active surveillance were assigned to three groups, and 49 completed the study. They consumed 300mL of soup weekly for 12 months, with 72, 214, or 492μmol of GLR per serving.
- Participants
- United Kingdom · prostate cancer under active surveillance
61 assigned / 49 completed - Intake and observation
- Broccoli soup 300mL/week
three GLR-content groups · 12 months - Measures
- RNA analysis of prostate tissue
Study context
A food intervention study examining gene expression in tissue from patients with prostate cancer under active surveillance.
Original paper and sources
Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial.
- Journal
- The American journal of clinical nutrition · 2019 · 109(4): 1133-1144
- First published
- 2019-04-01