Sedlak · 2018 · Molecular neuropsychiatry
Blood and brain glutathione after sulforaphane intake
Would the antioxidant glutathione change in both blood and brain after sulforaphane intake?
Human · biomarker pilot study
Key findings
Blood antioxidant markers
Blood glutathione (GSH) increased after seven days of intake. This was a short-term biomarker response.
Relationship between blood and thalamus changes
A positive correlation was reported between pre-to-post intake ratios of GSH in blood and thalamus.
Metabolic responses in blood and brain
Blood tests and brain imaging were used to explore changes in glutathione.
Study design
Nine healthy participants consumed sulforaphane 100μmol daily for seven days. Blood tests and 7-tesla magnetic resonance spectroscopy were used to examine metabolite changes in the anterior cingulate cortex, hippocampus, and thalamus.
- Participants
- United States · nine healthy adults
small study without a comparison group - Intake and observation
- Sulforaphane 100μmol/day
7 days · blood tests and brain imaging - Measures
- Blood GSH · brain magnetic resonance spectroscopy
Study context
This was a seven-day before-and-after comparison in nine healthy adults. Antioxidant metabolites in blood and brain were measured.
Original paper and sources
Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study.
- Journal
- Molecular neuropsychiatry · 2018 · 3(4): 214-222
- First published
- 2018-04-17