Li · 2022 · Frontiers in cellular neuroscience
Brain injury and NRF2 in mice exposed to intermittent hypoxia
How did sulforaphane affect brain injury caused by repeated hypoxia exposure?
Animal · hypoxia mechanism experiment
Key findings
Fewer errors on memory tests
Fewer working and reference memory errors were observed in hypoxic mice given sulforaphane.
Changes in hippocampal injury markers
Markers of apoptosis and lipid oxidative damage decreased, while antioxidant enzyme markers increased.
NRF2 and autophagy
NRF2 nuclear translocation and changes in autophagy-related proteins were observed together, suggesting a possible pathway.
Study design
Mice were exposed to chronic intermittent hypoxia for four weeks. Sulforaphane 0.5mg/kg was injected intraperitoneally each day 30 minutes before hypoxia exposure, and maze memory tests and hippocampal tissue were analyzed.
- Participants
- Mouse · intermittent hypoxia model
simulating hypoxia in sleep apnea - Intake and observation
- Sulforaphane 0.5mg/kg/day
intraperitoneal injection · 4 weeks - Measures
- Maze test · hippocampal oxidative injury
Study context
Sulforaphane was injected intraperitoneally in mice in a hypoxic injury model.
Original paper and sources
Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice via Augmenting Nrf2 Nuclear Translocation and Autophagy.
- Journal
- Frontiers in cellular neuroscience · 2022 · 16: 827527
- First published
- 2022-03-24