Kishida · 2024 · The Journal of nutrition
Fruit and vegetable intake and long-term dementia risk
Would people who usually eat more fruit and vegetables have a different long-term risk of dementia with impairment in daily living?
Human · prospective observational study
Key findings
Highest and lowest intake groups
The adjusted hazard ratios for the highest quartile of total fruit and vegetable intake were 0.87 for men and 0.85 for women. Their respective 95% confidence intervals were 0.76–0.99 and 0.76–0.94.
Association with overall diet
Dietary vitamin C intake was also associated with lower dementia risk. The study analyzed usual diet data.
Usual diet and nutrient intake
Fruit, vegetable, and nutrient intake was measured.
Total Fruit and Vegetable Intake and Dementia Risk
Highest versus lowest quartile · adjusted hazard ratio (HR)
Line: 95% confidence interval · reference line 1 · observational association
42,643 participants · 4,994 dementia-related events
Read the original paper and sources ↓View values and units
| Group | Estimate | 95% confidence interval |
|---|---|---|
| Men | 0.87 | 0.76 ~ 0.99 |
| Women | 0.85 | 0.76 ~ 0.94 |
Study design
A food frequency questionnaire was administered to 42,643 people aged 50–79 in Japan. The association between intake and risk was analyzed using dementia-related functional impairment records from long-term care insurance data.
- Participants
- Japan · 42,643 people aged 50–79
4,994 dementia events observed - Intake and observation
- Usual fruit and vegetable intake survey
dementia ascertainment: 2006–2016 - Measures
- 4,994 dementia events · hazard ratio (HR)
Study context
This observational study followed the association between usual diet and long-term dementia risk. Hazard ratios were statistically adjusted for lifestyle and other factors.
Original paper and sources
Fruit and Vegetable Intake and Risk of Disabling Dementia: Japan Public Health Center Disabling Dementia Study.
- Journal
- The Journal of nutrition · 2024 · 154(6): 1842-1852
- First published
- 2024-04-08