Kikuchi · 2015 · World journal of gastroenterology
Liver enzymes and oxidative damage markers in men with fatty liver
Would sprout extract change liver enzymes and oxidative damage markers in men with fatty liver?
Human and animal · controlled human trial and mechanistic research
Key findings
Changes in liver enzymes from baseline
Median ALT in the intake group decreased from 54.0 to 48.5IU/L, and γ-GTP also decreased. The between-group difference in liver enzyme reductions was not clear.
Oxidative damage markers
Median urinary 8-OHdG decreased from 6.66 to 5.49ng/mg creatinine and was associated with changes in liver enzymes.
ALT · Before and After Intake
Median within the same group · IU/L
Within-group change; between-group difference not established
Men with fatty liver and elevated liver enzymes
Read the original paper and sources ↓View values and units
| Group | Value |
|---|---|
| Baseline | 54.0 |
| Month 2 | 48.5 |
Study design
Fifty-five men with fatty liver and elevated liver enzymes were enrolled; data from 52 were analyzed. They took sprout extract with GLR 30mg/day or placebo for two months, alongside a separate rat experiment.
- Participants
- Men with fatty liver and elevated liver enzymes
55 enrolled / 52 analyzed - Intake and observation
- GLR 30mg/day · sprout extract
2 months · placebo controlled - Measures
- ALT · γ-GTP · urinary 8-OHdG
Study context
A two-month human trial in men with fatty liver was conducted alongside a rat experiment on liver injury.
Original paper and sources
Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.
- Journal
- World journal of gastroenterology · 2015 · 21(43): 12457-12467
- First published
- 2015-11-01