He · 2024 · Molecular nutrition & food research
Liver and gut microbiota in mice with circadian disruption
Under combined high-fat diet and circadian disruption, how might sulforaphane affect liver metabolism and gut microbes in mice?
Animal · high-fat diet and circadian model
Key findings
Liver fat and intestinal tissue
Results pointed toward reduced liver fat accumulation and markers of intestinal inflammatory injury.
Metabolites and microbial composition
Amino acid and bile acid metabolites and several gut bacterial groups changed. Correlations between liver metabolites and microbes were analyzed.
Circadian clock proteins
Expression of circadian-related proteins in the hypothalamus and liver also changed.
Study design
The model used mice with disrupted circadian rhythms fed a high-fat diet. Liver tissue and metabolites, intestinal tissue, fecal microbiota, and circadian clock proteins in the hypothalamus and liver were analyzed.
- Participants
- Mouse · circadian disruption model
combined with a high-fat diet - Intake and observation
- Sulforaphane administration
clock proteins, liver, and gut assessed - Measures
- Liver metabolites · 16S microbiome analysis
Study context
A mouse study of liver and gut metabolism under combined high-fat diet and circadian disruption.
Original paper and sources
Sulforaphane Improves Liver Metabolism and Gut Microbiota in Circadian Rhythm Disorder Mice Models Fed With High-Fat Diets.
- Journal
- Molecular nutrition & food research · 2024 · 68(21): e2400535
- First published
- 2024-10-03