Ferreira-Chamorro · 2018 · Frontiers in pharmacology
Animal study of sensitized neural responses to pain
Could sulforaphane reduce pain from light touch after nerve injury?
Animal · mechanistic study of neuropathic pain
Key findings
Hypersensitivity to touch, cold, and heat decreased.
Repeated sulforaphane administration reduced excessive pain responses in mice with sciatic nerve injury.
Cellular defense and neuroinflammation changed together.
Measures of antioxidant defense pathways and nervous-system inflammation changed.
Shows why possible pain-modulating mechanisms are studied
Pain hypersensitivity and cellular defense pathways after nerve injury were examined in mice.
Study design
A chronic sciatic nerve constriction model assessed mechanical and cold allodynia and heat hyperalgesia. Antioxidant signaling and microglial activation measures in the brain and spinal cord were also analyzed.
- Participants
- Mice with sciatic nerve injury
Compared with surgical controls - Intake and observation
- Sulforaphane 10 mg/kg/day · intraperitoneal injection
Days 14–28 after surgery · 15 days - Measures
- Allodynia · hyperalgesia · NRF2/HO-1 · neuroinflammation measures
Study context
Pain hypersensitivity after nerve injury was assessed in mice injected intraperitoneally with 10 mg/kg sulforaphane for 15 days.
Original paper and sources
Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice.
- Journal
- Frontiers in pharmacology · 2018 · 9: 1332
- First published
- 2018-11-20