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Egner · 2014 · Cancer prevention research (Philadelphia, Pa.)

Sprout beverage and pollutant excretion markers

Would drinking a broccoli sprout beverage daily change urinary excretion of metabolites of some air pollutants?

Human · 12-week randomized controlled trial

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Key findings

Benzene metabolite excretion

Excretion of benzene's glutathione-conjugated metabolite was 61% higher than with placebo. The effect was sustained during the trial.

Different results by compound

Acrolein metabolite excretion was 23% higher, but the same difference was not observed for crotonaldehyde.

Excretion markers measured in urine

Urinary metabolites were the measure assessed.

Excretion of Air Pollutant Metabolites

Increase in urinary excretion versus placebo · %

Excretion of Air Pollutant Metabolites chart. Exact values and units appear in the data table below.

Excretion of each compound’s metabolite

291 participants · 12 weeks

Read the original paper and sources ↓
View values and units
Increase in urinary excretion versus placebo · %
GroupValue
Benzene metabolite61
Acrolein metabolite23

Study design

In Qidong, China, 291 adults were compared over 12 weeks with sprout beverage or placebo. The beverage supplied GLR 600μmol and SFN 40μmol daily.

Participants
China · 291 adults exposed to air pollution
residents of a polluted area
Intake and observation
GLR 600μmol/day
+ SFN 40μmol/day
sprout beverage · 12-week placebo comparison
Measures
Urinary benzene and acrolein metabolites

Study context

A beverage containing GLR and SFN was used to evaluate urinary excretion of air pollutant metabolites.

Original paper and sources

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Journal
Cancer prevention research (Philadelphia, Pa.) · 2014 · 7(8): 813-823
First published
2014-06-09