Davinelli · 2024 · Cellular and molecular neurobiology
NRF2 linking sleep and oxidative stress
How are sleep and oxidative stress related, and where does NRF2, a regulator of cellular defenses, fit in?
Literature review · mechanistic review
Key findings
A reciprocal relationship
The study also describes the oxidative burden that accumulates during wakefulness and the role of sleep in regulating it. Reactive oxygen species can cause damage and also participate in signaling.
The role of NRF2
NRF2 is described as a factor that senses cellular oxidative status and regulates defense gene responses.
Questions for follow-up research
The authors proposed a link between NRF2 regulation and sleep problems as a topic for future research.
Study design
This review summarized existing literature on sleep deprivation, obstructive sleep apnea, circadian disruption, and their relationship to NRF2.
- Participants
- Review of existing studies
Analysis of existing literature - Intake and observation
- Sleep, oxidative stress, and NRF2
review of existing literature - Measures
- Sleep homeostasis · redox regulation
Study context
A mechanistic review of existing literature on the relationship among sleep, oxidative stress, and NRF2.
Original paper and sources
Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2.
- Journal
- Cellular and molecular neurobiology · 2024 · 44(1): 52
- First published
- 2024-06-25