Davidson · 2024 · medRxiv · preprint
Pain changes in people with knee osteoarthritis who ate broccoli soup
Did pain change when people with knee osteoarthritis ate broccoli soup for 12 weeks?
Human · double-blind randomized pilot trial · preprint
Key findings
Change in knee pain at 12 weeks
In a pilot trial of 24 participants, the baseline-adjusted improvement in pain versus placebo was 4.2 points on a 20-point scale (95% CI 1.03–7.38). Seven participants ate the broccoli soup.
Knee Pain · Difference in 12-Week Change
Pain reduction versus control · points on a 0–20 scale
Point: estimate / line: 95% confidence interval · farther right indicates less pain
7 assigned to broccoli / 17 to control · pre-peer-review feasibility study
Read the original paper and sources ↓View values and units
| Group | Estimate | 95% confidence interval |
|---|---|---|
| Difference versus placebo | 4.2 | 1.03 ~ 7.38 |
Study design
Participants with pain and radiographic osteoarthritis were assigned broccoli soup or a sensory-matched control soup. The primary outcome was change in WOMAC pain score from baseline to week 12.
- Participants
- 24 adults aged 50 years or older with knee osteoarthritis
Broccoli group 7 / control group 17 - Intake and observation
- Soup 300 mL · GLR 120 μmol
Four days/week · once on intake days · 12 weeks - Measures
- WOMAC pain, 0–20 points · function · feasibility of intake
Study context
Broccoli soup high in glucoraphanin was consumed four days per week for 12 weeks while knee pain was assessed.
Observed during intake: Three intervention-related adverse events were reported.
Original paper and sources
The BRoccoli In Osteoarthritis (BRIO study) - A randomised controlled feasibility trial to examine the potential protective effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis
- Journal
- medRxiv · preprint · 2024 ·
- First published
- 2024-06-21
medRxiv preprint manuscript · Study conditions and preliminary results from a preprint awaiting peer review.